Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-Xin Yang, Zhen-Zhen Ma, Lin Huang, Yan-Peng An, Yi-Yuan Yuan, Yan Lin, Wei Xu, Yao Li, Peng-Cheng Lin, Jing Cao, Jian-Yuan Zhao, Shi-Min Zhao*.Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/ glutamate ratio to inhibit epilepsy.(2024)Cell Discovery, Vol 10,1, DOI 10.1038/s41421-023-00636-x

Kai-Hui Zhang, Fei-Fei Zhang, Zhi-Ling Zhang , Ke-Fei Fang, Wen-Xing Sun, Na Kong, Min Wu, Hai-Ou Liu, Yan Liu, Zhi Li, Qing-Qing Cai, Yang Wang, Quan-Wei Wei, Peng-Cheng Lin, Yan Lin, Wei Xu, Cong-Jian Xu1* , Yi-Yuan Yuan* , Shi-Min Zhao*.Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation.(2024) Protein & Cell, DOI 10.1093/procel/pwad065

Yunzi Mao, Jiaojiao Zhang, Qian Zhou, Xiadi He, Zhifang Zheng, Yun Wei, Kaiqiang Zhou, Yan Lin, Haowen Yu,Haihui Zhang, Yineng Zhou, Pengcheng Lin, Baixing Wu, Yiyuan Yuan, Jianyuan Zhao, Wei Xu*, Shimin Zhao*. Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation.(2024) Cell Research, DOI 10.1038/s41422-023-00864-6

Yingji Chen, Dongyue Jiao, Yang Liu, Xiayun Xu, Yilin Wang, Xiaona Luo, Hexige Saiyin, Yao Li, Kun Gao, Yucai Chen, * Shi-Min Zhao, *Lixiang Ma, *Chenji Wang. * FBXL4 mutations cause excessive mitophagy via BNIP3/BNIP3L accumulation leading to mitochondrial DNA depletion syndrome. (2023) Cell Death & Differentiation, DOI10.1038/s41418-023-01205-1

Hu Song-Hua, Feng Yu-Yang, Yang Yuan-Xin,  Ma Hui-Da, Zhou Shu-Xian, Qiao Ya-Nan, Zhang Kai-Hui, Zhang Lei, Huang Lin, Yuan Yi-Yuan, Lin Yan, Zhang Xin-Yan, LiYao, Li Hai-Tao, Zhao Jian-Yuan, *Xu Wei, * Zhao Shi-Min. *Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle. (2023) Nature Metabolism, 5, 626-641

Zhao Rui, Cai Ke, Yang Jing-Jing, Zhou Qian, Cao Wei, Xiang Jie, Shen Yi-Hui, Cheng Lei-Lei, Zang Wei-Dong, Lin Yan, Yuan Yi-Yuan, Xu Wei, Tao Hui, * Zhao Shi-Min, *Zhao Jian-Yuan*. Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response.(2023) Cell Reports,43,4,112400

Qian Zhou, Wan-Wan Sun, Jia-Cong Chen, Hui-Lu Zhang, Jie Liu, Yan Lin, Peng-Cheng Lin, Bai-Xing Wu, Yan-Peng An, Lin Huang, Wen-Xing Sun, Xin-Wen Zhou, Yi-Ming Li, Yi-Yuan Yuan, Jian-Yuan Zhao, Wei Xu,* Shi-Min Zhao*. Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ.(2022) Nature Communications 13:4291

Song-Hua Hu, Xia-Di He, Ji Nie, Jun-Li Hou, Jiang Wu, Xiao-Yan Liu, Yun Wei, Hui-Ru Tang,Wen-Xing  Sun, Shu-Xian Zhou, Yi-Yuan Yuan, Yan-Peng An, Guo-Quan Yan, Yan Lin, Peng-Cheng Lin,Jean J. Zhao, Ming-Liang Ye, * Jian-Yuan Zhao, * Wei Xu, * and Shi-Min Zhao, * Methylene-bridge tryptophan  fatty acylation regulates PI3K-AKT signaling and glucose uptake.(2022) Cell Reports,38,110509

Liang Zhang, Jianong Zhang, Yan Liu, Pingzhao Zhang, Ji Nie, Rui Zhao, Qin Shi, Huiru Sun, Dongyue Jiao, Yingji Chen, Xiaying Zhao, Yan Huang, Yao Li, Jian-Yuan Zhao, Wei Xu, Shi-Min Zhao*, Chenji Wang*. Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex.(2021) Cell Death & Disease, vol12,7, 10.1038/s41419-021-03908-0

Kaihui Zhang, Wenxing Sun, Yi Liu, Yuqiang Lv, Daisen Hou, Yan Lin, Wei Xu, Jianyuan Zhao, Zhongtao Gai*, Shimin Zhao* and Yiyuan Yuan*.SINO Syndrome Causative KIDINS220/ARMS Gene Regulates Adipocyte Differentiation.(2021) Frontiers in Cell and Developmental Biology, 10.3389/ fcell. 2021. 619475

Jianong Zhang, Liang Zhang, Ji Nie, Yan Lin, Yao Li, Wei Xu, Jian-Yuan Zhao, Shi-Min Zhao*, Chenji Wang*.Calcineurin inactivation inhibits pyruvate dehydrogenase complex activity and induces the Warburg effect.(2021) Oncogene, 10.1038/s41388-021-02065-0

Zhang KH, Liu S, Gu WJ, Lv YQ, Yu HH, Gao M, Wang D, Zhao JY, Li XY, Gai ZT , Zhao SM*, Liu Y*,Yuan YY*. Transmission of a Novel Imprinting Center Deletion Associated With Prader-Willi  Syndrome Through Three Generations of a Chinese Family: Case Presentation, Differential Diagnosis, and  a  Lesson Worth Thinking About. (2021) Frontiers In Genetics,Vol 12

Rui Qin, Chen Zhao, Chen-Ji Wang, Wei Xu, Jian-Yuan Zhao, Yan Lin, Yi-Yuan Yuan, Peng-Cheng Lin, Yao Li, Shimin Zhao* , Yan Huang*.Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation.(2021) Journal For Immunotherapy Of Cancer,Vol 9,7

Jiao-Jiao Zhang, Ting-Ting Fan, Yun-Zi Mao, Jun-Li Hou, Meng Wang, Min Zhang, Yan Lin, Lei Zhang, Guo-Quan Yan, Yan-Peng An, Jun Yao, Cheng Zhang , Peng-Cheng Lin, Yi-Yuan Yuan, Jian-Yuan Zhao, Wei Xu* , Shi-Min Zhao*.Nuclear dihydroxyacetone phosphate signals nutrient sufficiency and cell cycle phase to global histone acetylation.(2021) Nature Metabolism, Vol 3,6,859

Xinyu Mei# , Dashi Qi#, Ting Zhang#, Ying Zhao#, Li Jin, Junli Hou, Jianhua Wang,Yan Lin, Yu Xue, Pingping Zhu, Zexian Liu, Lei Huang, Ji Nie, Wen Si, Jingyi Ma, Jianhong Ye, Richard H Finnell, Hexige Saiyin, Hongyan Wang*, Jianyuan Zhao*, Shimin Zhao*, Wei Xu*. Inhibiting MARSs reduces Hyperhomocysteinemia-associated neural tube and congenital heart defects. (2020) EMBO Molecular Medicine, Vol 12,3,e9469

Yuan-Yuan Qu, Rui Zhao, Hai-Liang Zhang, Qian Zhou, Fu-Jiang Xu, Xuan Zhang, Wen-Hao Xu, Ning Shao, Shu-Xian Zhou, Bo Dai, Yao Zhu, Guo-Hai Shi, Yi-Jun Shen, Yi-Ping Zhu, Cheng-Tao Han, Kun Chang, Yan Lin, Wei-Dong Zang, Wei Xu, Ding-Wei Ye*, Shi-Min Zhao*, and Jian-Yuan Zhao*. Inactivation of the AMPK–GATA3–ECHS1 Pathway Induces Fatty Acid Synthesis That Promotes Clear Cell Renal Cell Carcinoma Growth. (2020) Cancer Research, Vol80,2,319-333

Yang Li, Cui-Fang Yao, Fu-Jiang Xu, Yuan-Yuan Qu, Jia-Tao Li, Yan Lin, Zhong-Lian Cao,Peng-Cheng Lin, Wei Xu, Shi-Min Zhao*, Jian-Yuan Zhao*. APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression. (2019) Nature communications,10:2502

Wang, D, Zhao, R, Qu, YY, Mei, XY , Zhang, X, Zhou, Q, Li, Y , Yang, SB, Zuo, ZG, Chen, YM , Lin, Y, Xu,W, Chen, C, Zhao,SM*, Zhao,JY*, Colonic Lysine Homocysteinylation Induced by High-Fat Diet Suppresses DNA Damage Repair.(2018)Cell Reports,Vol 25,2,398

Q. Zhang, B.l. Bai, X.y. Mei, Ch.l. Wan, H.y. Cao, D. Li, Sh. Wang, M. Zhang, Zh.G. Wang, J.X. Wu, H.Y. Wang, J.SH. Huo, G.Q. Ding, J.Y. Zhao, Q. Xie, L. Wang，Zh.Y Qiu, Sh.M. Zhao*,T. Zhang*. Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects. (2018) Nature communications, 9:3436

Xia-Di He, Wei Gong, Jia-Nong Zhang, Ji Nie, Cui-Fang Yao, Fu-Shen Guo, Yan Lin, Xiao-Hui Wu, Feng Li, Jie Li, Wei-Cheng Sun, En-Duo Wang, Yan-Peng An, Hui-Ru Tang, Guo-Quan Yan, Peng-Yuan Yang, Yun Wei, Yun-Zi Mao, Peng-Cheng Lin, Jian-Yuan Zhao, Yanhui Xu*, Wei Xu*, and Shi-Min Zhao*. Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations.（2018）Cell Metabolism,27,1,151-167

Ya-Kun Zhang, Yuan-Yuan Qu, Yan Lin, Xiao-Hui Wu, Hou-Zao Chen, Xu Wang, Kai-Qiang Zhou, Yun Wei, Fushen Guo, Cui-Fang Yao, Xia-Di He, Li-Xia Liu, Chen Yang, Zong-Yuan Guan, Shi-Dong Wang, Jianyuan Zhao, De-Pei Liu*, Shi-Min Zhao*, Wei Xu*. Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients.(2017) Nature communications,8:464

Dan Wang, Feng Wang, Kai-Hu Shi, Hui Tao, Yang Li, Rui Zhao, Han Lu, Wenyuan Duan, Bin Qiao, Shi- Min, Zhao*, Hongyan Wang*, Jian-Yuan Zhao*. Lower Circulating Folate Induced by a Fidgetin Intronic Variant Is Associated With Reduced Congenital Heart Disease Susceptibility.(2017)Circulation,Vol 135,18,1733-1748

Li, F., He, X., Ye, D., Lin, Y., Yu, H., Yao, C., Huang, L., Zhang, J., Wang, F., Xu, S., Wu, X., Liu, L., Yang, C., Shi, J., He, X., Liu, J., Qu, Y., Guo, F., Zhao, J., Xu, W.*, and Zhao, S*. NADP(+)-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance. (2015) Molecular cell 60, 4,661-675

Zhang, T., Wang, S., Lin, Y., Xu, W., Ye, D., Xiong, Y.*, Zhao, S.*, and Guan, K. L.*Acetylation negatively regulates glycogen phosphorylase by recruiting proteinphosphatase 1.(2012) Cell metabolism15,1,75-87

Yaohui Chen, Jinye Zhang, Yan Lin, Qunying Lei, Kun-Liang Guan, Shimin Zhao*& Yue Xiong*. Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. (2011) EMBO reports VOL 12,6,534-541

Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S. H., Ito, S., Yang, C., Wang, P., Xiao, M. T., Liu, L. X., Jiang, W. Q., Liu, J., Zhang, J. Y., Wang, B., Frye, S., Zhang, Y., Xu, Y. H., Lei, Q. Y., Guan, K. L., Zhao,S.M.*, and Xiong, Y.* Oncometabolite 2- hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases.(2011) Cancer cell 19, 17-30

Jiang, W., Wang, S., Xiao, M., Lin, Y., Zhou, L., Lei, Q., Xiong, Y., Guan, K. L., and Zhao, S.* Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. (2011) Molecular cell 43, 1,33-44

Kun-Liang Guan, Wei Yu, Yan Lin, Yue Xiong* & Shimin Zhao*. Generation of acetyllysine antibodies and affinity enrichment of acetylated peptides.(2010) nature protocols VOL.5,9,1583-1595

Wang, Q., Zhang, Y., Yang, C., Xiong, H., Lin, Y., Yao, J., Li, H., Xie, L., Zhao, W., Yao, Y., Ning, Z. B., Zeng, R., Xiong, Y., Guan, K. L., Zhao, S.*, and Zhao, G. P.* Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. (2010) Science, Vol 327,5968,1004-1007

Shimin Zhao, Wei Xu, * Wenqing Jiang, * Wei Yu, Yan Lin, Tengfei Zhang, Jun Yao, Li Zhou, Yaxue Zeng, Hong Li, Yixue Li, Jiong Shi, Wenlin An, Susan M. Hancock, Fuchu He, Lunxiu Qin, Jason Chin, Pengyuan Yang, Xian Chen, Qunying Lei, Yue Xiong, #Kun-Liang Guan#. Regulation of Cellular Metabolism by Protein Lysine Acetylation. (2010) Science, Vol 327,5968,1000-1004

Shimin Zhao, Yan Lin, * Wei Xu, * Wenqing Jiang,* Zhengyu Zha, Pu Wang, Wei Yu, ZhiqiangLi, Lingling Gong, Yingjie Peng, Jianping Ding, Qunying Lei, Kun-Liang Guan,# Yue Xiong#. Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1.(2009) Science, Vol324, 5924, 261-265

Wei Yu, Yan Lin, Jun Yao, Wei Huang, Qunying Lei, Yue Xiong, Shimin Zhao*, Kun Liang Guan*. Lysine 88 Acetylation Negatively Regulates Ornithine Carbamoyltransferase Activity in Response to Nutrient Signals.(2009) J. Biol. Chem.Vol 284,20,13669-13675